银屑病关节炎患者有较高的血清内脂素抵抗
摘要：目的：银屑病关节炎是与银屑病和银屑病指甲病变相关的一种慢性炎症性关节炎。脂肪细胞因子认为影响胰岛素抵抗和糖尿病的发病。然而想在发现脂肪细胞因子在与自身免疫性疾病有关的炎症进展中扮演了重要的角色，这篇研究的目的是，研究银屑病关节炎患者血清内脂素、抵抗素和脂联素水平与疾病严重程度和胰岛素抵抗的关系。方法：总共67位研究对象（28位银屑病关节炎，39位健康对照组）无高血压及糖尿病病史。检测所有患者的内脂素、抵抗素和脂联素水平和胰岛素抵抗程度（用内稳态模型检测[HOMA-IR]）。银屑病关节炎疾病活动度评估使用银屑病关节炎疾病活动指数（DAPSA）评估。结果：银屑病关节炎患者与健康对照组相比有相对较高的内脂素、抵抗素和脂联素水平（P＜0.05）。逻辑回归分析，以下的变量可能与银屑病复杂的发病机理有关：脂联素（P=0.，OR=3.1，95%可信区间1.6-6.0），抵抗素（P=,OR=1.8,95%可信区间=1.2-2.9）和内脂素（P=0.,OR=3.9,95%可信区间=1.1-13.9)。相比之下，我们没有发现银屑病疾病活动指数与脂肪细胞因子之间的相关性。结论：疾病活动度与脂肪细胞因子之间无相关性。银屑病关节炎患者血清中有较高的脂联素、抵抗素和内脂素水平，其在银屑病关节炎中的病理生理学意义有待进一步研究。
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AIM:Psoriaticarthritis(PsA)isaninflammatoryformofarthritistypicallyassociatedwithpsoriasisand/orpsoriaticnaildisease.Adipocytokineswereoncethoughttoinfluencedevelopmentof(only)insulinresistanceanddiabetesmellitus.However,itisnowclearthatadipocytokinesplayimportantrolesindevelopmentoftheinflammationassociatedwitheitherautoimmuneorauto-inflammatorydisorders.Inthepresentstudy,wemeasuredchangesintheserumlevelsofadiponectin,resistinandvisfatin,andtheassociationsofsuchchangeswiththeextentofdiseaseactivityandinsulinresistanceinPsApatients.MATERIALANDMETHODS:Atotalof67subjects(28withPsAand39healthycontrols)withouthypertensionordiabetesmellituswereenrolled.Adiponectin,resistinandvisfatinlevels,andtheextentofinsulinresistance(assayedusingthehomeostasismodel[HOMA-IR]),weremeasuredinallsubjects.AssessmentofPsAdiseaseactivitywasdonewiththeDiseaseActivityIndexforPsoriaticArthritis(DAPSA).RESULTS:Psoriaticarthritispatientshadconsiderablyhigherserumlevelsofadiponectin,resistinandvisfatinthandidhealthycontrols(allP0.05).Inthelogisticregressionanalysis,thefollowingvariablesmaycontributeto北京白癜风较好北京白癜风大概需要多少钱